A new targeted cancer therapy approach based on metabolic synthetic lethality
Metabomed is developing a therapeutic strategy based on new drugs that inhibit metabolic enzymes which are vital for cancer cells’ survival. Metabomed identifies reprogrammed metabolic pathways specific and essential to cancer cells with genetically-enforced metabolic alterations. Those “induced essential” metabolic pathways uniquely support the growth and survival of cancer cells.
Our goal: to identify and pharmacologically inhibit essential metabolic targets to specifically prevent cancer growth while limiting damage to surrounding healthy tissues.
at the core
Using genetics to stratify patients in order to identify those most suited for novel treatments while limiting side effectsRead More
Metabomed is running several programs against targets that form synthetic lethal pairs with inactivated metabolic genesRead More
Exploiting the groundbreaking work of genomic and metabolic pathways mappingRead More
Metabomed is a drug discovery company in the field of cancer metabolism. The Company is developing a proprietary target identification platform based on computational biology, genomics and metabolomics. The platform identifies metabolic pathways that arise uniquely in cancers that enable and support their growth. These discoveries are used to develop small molecules that specifically target the reprogrammed cancer cells’ metabolism to halt their growth. Since these molecules inhibit divergent pathways that are specific to cancer cells, the therapies will not target healthy surrounding tissues. Metabomed is a privately held company based in Israel and supported by the groundbreaking science of its scientific founders.
Exploring the genomic landscape of patients suffering from a particular type of cancer.
Based on this genomic data, specific cellular metabolic deficits are identified.
The platform then focuses on metabolic pathways that enable cancer cells to overcome and survive the metabolic deficiencies and set the disease state into motion.
Drug discovery is then based on targets that form synthetic lethal pairs with inactivated metabolic genes, to disrupt the cancer cells’ inherent survival mechanisms and prevent cancer cells from adapting to their metabolic constraints.