Careers

Location- Yavne

Job description

Metabomed, a promising cancer drug discovery biotech company is looking for a Cell-biology Scientist.

The position is for a hands-on cell biology scientist and requires a PhD in life science. The ideal candidate would have a vast experience in various cell biology methods, and in cancer biology and biochemical assays. He/she will be responsible for conducting biological experiments as part of an effort to discover and develop new cancer therapeutics.

Some of the specific areas of research include validating potential cancer targets, target deconvolution, developing and performing biochemical and cellular assays and elucidating compound’s mode of action.

Minimum Requirements:

• This position requires a PhD in cell biology.
• The candidate must be experienced in standard cell biology techniques.
• The candidate should have experience in biochemical assay development.
• Candidate must be able to design and troubleshoot assays and experiments independently.
• Good written communication and reporting skills in English

Advantage

• Experience in cancer biology
• Familiar with small-molecule drug discovery process
• Previous experience in a pharmaceutical or biotech companies
• Familiar with cutting-edge techniques in cell biology, biochemistry and biophysics.

Protein Chemistry Scientist with Cell Biologyexperience

Metabomed, a promising startup in Merck incubator center, seeks an enthusiastic, experienced Protein Chemistry Scientist with Cell Biology experienceto join our R&D team in Yavne.  The position is for a hands-on senior scientist with a PhD in life science thatwill be responsible for conducting biological experiments as part of an effort to discover and develop new cancer therapeutics.

As a member of an interdisciplinary team, this individual will be expected to employ proteomics approaches to support target identification / deconvolution, target engagement, and mode-of-action (MOA) elucidation efforts in several drug discovery programs.

The ideal candidate would have extensive experience in various quantitative chemo-proteomics methods and data analysis in addition to experimental skillsin biochemistry and cell biology.

Functions and Duties

Contribute to developing and implementing proteomic technologies to investigate target identification / deconvolution of small-molecule compounds identified from screens.
Perform cell-based proteome profiling studies to support target identification, target engagement, and mode-of-action (MOA) elucidation efforts in multiple drug discovery programs.
Design and execute experiments independently; accurately record, analyze and presentresults.
Contribute to the effective operation of the lab by sharing the responsibilities.
Collaborate with CROs and academic labs to compliment internal proteomic/chemical biology capabilities.

Skills and Experience

Ph.D. in Biochemistry, Cell-biology, or related discipline with relevant experience.
Experience with chemical-affinity enrichment to selectively enrich proteins and chemical biology techniques using probes (covalent and/or photoaffinity).
Experiences withStable isotope labeling with amino acids (SILAC)or other quantitative proteomics techniquesis an advantage.
Experience in isolating protein from complex biological samples and sample processing workflow for LC-MS analysis.
Experience in conducting, analyzing and interpreting LC-MS/MS proteomics data is an advantage.
Ability to plan and troubleshoot experiments independently.
Attention to detail and strong record-keeping skills.
Strong communication and collaboration skills.
Flexibility to rapidly adapt workplans to changing priorities and deadlines.