Protein Chemistry Scientist with Cell Biologyexperience Metabomed, a promising startup in Merck incubator center, seeks an enthusiastic, experienced Protein Chemistry Scientist with Cell Biology experienceto join our R&D team in Yavne. The position is for a hands-on senior scientist with[...]
Protein Chemistry Scientist with Cell Biologyexperience
Metabomed, a promising startup in Merck incubator center, seeks an enthusiastic, experienced Protein Chemistry Scientist with Cell Biology experienceto join our R&D team in Yavne. The position is for a hands-on senior scientist with a PhD in life science thatwill be responsible for conducting biological experiments as part of an effort to discover and develop new cancer therapeutics.
As a member of an interdisciplinary team, this individual will be expected to employ proteomics approaches to support target identification / deconvolution, target engagement, and mode-of-action (MOA) elucidation efforts in several drug discovery programs.
The ideal candidate would have extensive experience in various quantitative chemo-proteomics methods and data analysis in addition to experimental skillsin biochemistry and cell biology.
Functions and Duties
Contribute to developing and implementing proteomic technologies to investigate target identification / deconvolution of small-molecule compounds identified from screens.
Perform cell-based proteome profiling studies to support target identification, target engagement, and mode-of-action (MOA) elucidation efforts in multiple drug discovery programs.
Design and execute experiments independently; accurately record, analyze and presentresults.
Contribute to the effective operation of the lab by sharing the responsibilities.
Collaborate with CROs and academic labs to compliment internal proteomic/chemical biology capabilities.
Skills and Experience
Ph.D. in Biochemistry, Cell-biology, or related discipline with relevant experience.
Experience with chemical-affinity enrichment to selectively enrich proteins and chemical biology techniques using probes (covalent and/or photoaffinity).
Experiences withStable isotope labeling with amino acids (SILAC)or other quantitative proteomics techniquesis an advantage.
Experience in isolating protein from complex biological samples and sample processing workflow for LC-MS analysis.
Experience in conducting, analyzing and interpreting LC-MS/MS proteomics data is an advantage.
Ability to plan and troubleshoot experiments independently.
Attention to detail and strong record-keeping skills.
Strong communication and collaboration skills.
Flexibility to rapidly adapt workplans to changing priorities and deadlines.
