Careers

Location- Yavne

Job description

Metabomed, a clinical stage cancer drug-discovery biotech company is looking for a Research assistant for cancer cell biology.

The position is for a hands-on research assistant for mammalian tissue culture work and requires an experienced MSc in life science. The ideal candidate would have a vast experience in tissue culture and cell biology techniques. He/she will take part in conducting biological experiments as part of an effort to discover and develop new cancer therapeutics.

Some of the specific areas of research include: validating potential cancer targets, establishing stable cell-lines, developing and performing biochemical and cell-based assays to support drug discovery efforts.

Contribute to the effective operation of the lab by sharing the responsibilities of preparing buffers and reagents, ordering supplies and maintaining equipment.

Minimum Requirements:

• MSc in cell biology with a minimum of 2 years’ experience
• The candidate must be experienced in mammalian cell culture and cell biology techniques, including transfection protocols, stable cells selection, Western blotting and qPCR.
• Candidate must be able to design and troubleshoot assays and experiments independently

Advantage

• Previous experience in a pharmaceutical or biotech companies
• Experience in cell-free biochemical assays
• Experience in multiple gene transfer protocols (transfection, lentivirus and adenovirus infection), somatic gene silencing (RNAi) and ablation (CRISPR/Cas9) as well as experience in cells production and immortalization from primary tissues

Please contact: ifat.ariely@merckgroup.com

Protein Chemistry Scientist, Project Leader, PhD level

Location- Yavne

Job description

Metabomed, a clinical stage cancer drug discovery biotech company is looking for an enthusiastic, experienced Protein Chemistry Scientist with Cell Biology experience to join our R&D team in Yavne. The position is for a hands-on senior scientist with a PhD in life science that will be leading the proteomics approaches as part of an effort to discover and develop new cancer therapeutics.

The ideal candidate would have a vast experience in various proteomics methods in addition to experimental skills in cell biology and biochemistry.

FUNCTIONS AND DUTIES

Leading the development and implementation of proteomic approaches to investigate target identification / deconvolution of small-molecule hits from phenotypic screens and protein-ligand interactions.

Perform cell-based proteome profiling studies to support target identification and mode-of-action (MOA) elucidation efforts in multiple drug discovery programs.

SKILLS AND EXPERIENCE

• PhD. in Biochemistry, Cell-biology, or related discipline with relevant experience.
• Experience with chemical-affinity enrichment to selectively enrich proteins and chemical biology techniques using probes (covalent and/or photoaffinity).
• Experiences with Stable isotope labeling with amino acids (SILAC) or other quantitative proteomics techniques is an advantage.
• Experience in isolating protein from complex biological samples and sample processing workflow for LC-MS analysis.
• Experience in conducting, analyzing, and interpreting LC-MS/MS proteomics data is an advantage.

Please contact: ifat.ariely@merckgroup.com

Cell Biology Scientist / Project Leader, PhD level

Location- Yavne

Job description

Metabomed, a clinical stage cancer drug-discovery biotech company is looking for a Cell-biology Scientist/ Project Leader.

The position is for a hands-on cell biology scientist and requires a PhD in life science. The ideal candidate would have a vast experience in various cell biology methods, and in cancer biology and biochemical assays.

You will be responsible for conducting biological experiments as part of an effort to discover and develop new cancer therapeutics. You will be expected to both lead and contribute to one or more pipeline programs, working collaboratively to ensure the timely generation of critical program data to enable data-driven decisions.

Some of the specific areas of research include validating potential cancer targets, target deconvolution, developing and performing biochemical and cellular assays and elucidating compound’s mode of action.

Minimum Requirements:

• This position requires a PhD in cell biology or related field.
• The candidate must be experienced in standard cell biology techniques.
• Candidate must be able to design and troubleshoot assays and experiments independently.
• Good written communication and reporting skills in English

Advantage

• Experience in cancer biology
• Experience in biochemical assay development
• Familiar with small-molecule drug discovery process
• Previous experience in a pharmaceutical or biotech companies
• Familiar with cutting-edge techniques in cell biology, biochemistry and biophysics.

Please contact: ifat.ariely@merckgroup.com